The movie shows HEK293 cells stably expressing the engineered AgDD protein fused to GFP. Withdrawal of the Shield-1 ligand at time zero causes the AgDD molecules to aggregate in a rapid, uniform manner. Movie is from Miyazaki et al. Nature Communications 2016.
The lab concentrates on the invention of molecules and techniques that enable better studies of biological processes.
In short, we invent tools for biology and we are motivated by approaches that enable entirely new experiments with unprecedented control. These new techniques may also provide a window into mechanisms that cells use to maintain protein homeostasis. Protein quality control is a particular interest at present.Learn More »