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The following is a list of selected publications.
49. "Dicistronic regulation of fluorescent protein in the budding yeast Saccharomyces
cerevisiae." Edwards, S. R., Wandless, T. J. Yeast 2009, in press.
48. "A general method for conditional regulation of protein stability in living animals."
Sellmyer, M.A., Thorne, S. H., Banaszynski, L. A., Contag, C. H., and Wandless, T. J. CSH Protocols 2009 doi: 10.1101/pdb.prot5173. PDF
47. "Regulating protein stability in mammalian cells using small molecules." Hagan, E. L.,
Banaszynski, L. A., Chen, L.-C., Maynard-Smith, L. A., and Wandless, T. J. CSH
Protocols 2009 doi: 10.1101/pdb.prot5172. PDF
46. "The proteasome makes sense of mixed signals." Wandless, T. J. Nat. Chem. Biol., 2009, 5, 3-4.
45. "Recent progress with FKBP-derived destabilizing domains." Chu BW, Banaszynski LA, Chen LC, Wandless TJ. Bioorg Med Chem Lett., 2008 Sep 12. [PubMed]
44. "Chemical control of protein stability and function in living animals." Banaszynski, L. A.; Sellmyer, M. A.; Contag, C. H.; Wandless, T. J.; Thorne, S. H., Nature Medicine, 2008, (14)10, 1123-1127. PDF
43. "Synthesis and Analysis of Stabilizing Ligands for FKBP-Derived Destabilizing Domains." Grimley, J. S.; Chen, D. A.; Banaszynski, L. A.; Wandless, T. J. Bioorg. Med. Chem. Lett., 2008, 18, 759-761. PDF
42. "Rapid Control of Protein Levels in the Apicomplexan Parasite Toxoplasma gondii." Herm-Gotz, A.; Agop-Nersesian, C.; Munter, S.; Grimley, J. S.; Wandless, T. J.; Frischknecht, F.; Meissner, M. Nature Methods, 2007, 4, 1003-1005. PDF
41. "The Enantioselective Synthesis of Phomopsin B." Grimley, J. S.; Sawayama, A. M.; Tanaka, H.; Stohlmeyer, M. M.; Woiwode, T. F.; Wandless, T. J. Angew. Chem. Int. Ed., 2007, 46, 8157-8159. PDF
40. "A Directed Approach for Engineering Conditional Protein Stability using Biologically Silent Small Molecules." Maynard-Smith, L. A.; Chen, L.-C.; Banaszynski, L. A.; Ooi, A. G. L.; Wandless, T. J. J. Biol. Chem., 2007, 282, 24866-24872. PDF
39. "Rescue of Degradation-Prone Mutants of the FK506-Rapamycin Binding (FRB) Protein with Chemical Ligands." Stankunas, K.; Bayle, J. H.; Havranek, J. J.; Wandless, T. J.; Baker, D.; Crabtree, G. R.; Gestwicki, J. E. ChemBioChem, 2007, 8, 1162-1169. PDF
38. "The Rapamycin-Binding Domain of mTOR is a Destabilizing Domain." Edwards, S. R.; Wandless, T. J. J. Biol. Chem. 2007, 282, 13395-13401. PDF
37. "Engineering Small Molecule Specificity in Nearly Identical Cellular Environments." Sellmyer, M. A.; Stankunas, K.; Briesewitz, R.; Crabtree, G. R.; Wandless, T. J. Bioorg. Med. Chem. Lett., 2007, 17, 2703-2705. PDF
36. "SIK1 is a Class II HDAC Kinase that Promotes Survival of Skeletal Myocytes." Berdeaux, R.; Goebel, N., Banaszynski, L, A.; Takemori, H.; Wandless, T. J.; Shelton, G. D.; Montminy, M. Nature Medicine, 2007, 13, 597-603. PDF
35. "Plasma membrane dissociation of Ras superfamily small GTPases triggered by chemically-induced depletion of phosphoinositide lipid second messengers." Heo, W. D.; Inoue, T.; Park, W. S.; Kim, M. L.; Park, B. O.; Wandless, T. J.; Meyer, T. Science, 2006, 314, 1458-1461. PDF
34. "A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules." Banaszynski, L. A.; Chen, L.-C.; Maynard-Smith, L. A.; Ooi, A. G. L.; Wandless, T. J. Cell, 2006, 126, 995-1004. PDF
33. "Rapamycin Analogs with Differential Binding Specificity Permit Orthogonal Control of Protein Activity." Bayle, J.H.; Grimley, J.S.; Stankunas, K.; Gestwicki, J .E.; Wandless, T.J.; Crabtree, G. R. Chemistry & Biology, 2006, 13, 99-107. PDF 32. "Conditional Control of Protein Function." Banaszynski, L. A.; Wandless, T. J. Chemistry & Biology, 2006, 13, 11-21. PDF 31. "A Cell-Permeable Activity-Based Probe for Protein and Lipid Kinases." Yee, M. C.; Fas, S.C.; Stohlmeyer, M. M.; Wandless, T. J.; Cimprich, K. A. J. Biol. Chem., 2005, 280, 29053-29059. PDF 30. "Inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways." Inoue, T.; Heo, W.D.; Grimley, J.S.; Wandless, T. J.; Meyer, T. Nature Methods, 2005, 2, 415-418. PDF 29. "Characterization of the FKBP•rapamycin•FRB Ternary Complex." Banaszynski, L. A.; Liu, C. W.; Wandless, T. J. J. Am. Chem. Soc., 2005, 127, 4715-4721. PDF 28. "The Total Synthesis of Ustiloxin D and Considerations on the Origin of Selectivity of the Asymmetric Allylic Alkylation." Sawayama, A. M.; Tanaka, H.; Wandless, T. J. J. Org. Chem., 2004, 69, 8810-8820. PDF 27. "Quantitative Analyses of Bifunctional Molecules." Braun, P. D. and Wandless, T. J. Biochemistry, 2004, 43, 5406-5413. PDF 26. "Conditional Protein Alleles Using Knock-in Mice and a Chemical Inducer of Dimerization." Stankunas, K.; Bayle, J. H.; Gestwicki, J. E.; Lin, Y.-M.; Wandless, T. J.; Crabtree, G. R. Mol. Cell, 2003, 12, 1615-1624. PDF 25. "A Bifunctional Molecule That Displays Context-Dependent Cellular Activity." Braun, P. D.; Barglow, K. T.; Lin, Y.-M.; Akompong, T.; Briesewitz, R.; Ray, G. T.; Haldar, K.; Wandless, T. J. J. Am. Chem. Soc., 2003, 125, 7575-7580. PDF 24. "Enantioselective Total Synthesis of Ustiloxin D." Tanaka, H.; Sawayama, A. M.; Wandless, T. J.
J. Am. Chem. Soc., 2003, 125, 6864-6865. PDF 23. "Calcineurin Inhibitors and the Generalization of the Presenter Protein Strategy." Vogel, K. W.; Briesewitz, R.; Wandless, T. J.; Crabtree, G. R. In Advances in Protein Chemistry; E. M. Scolnick, Ed.; Academic Press: San Diego, CA, 2001, 56, 253-291. 22. "Mechanistic Studies of Affinity Modulation." Rosen, M. K.; Amos, C. D.; Wandless, T. J.
J. Am. Chem. Soc., 2000, 122, 11979-11982. PDF 21. "Synthesis of Flavonol Derivatives as Probes of Biological Processes." Tanaka, H.; Stohlmeyer, M. M.; Wandless, T. J.; Taylor, L. P. Tetrahedron Letters, 2000, 41, 9735-9739. PDF 20. "A Confederacy of Bunches: Fundamentals and Applications of a Self-Associating Protein." Wandless, T. J. Proc. Natl. Acad. Sci. USA, 2000, 97, 6921-6923. PDF 19. "Synthesis and Evaluation of Daunorubicin–Paclitaxel Dimers." Kar, A. K.; Braun, P. D.; Wandless, T. J. Bioorg. Med. Chem. Lett., 2000, 10, 261-264. PDF 18. "An Efficient Synthesis of β,γ-Dehydrovaline." Woiwode, T. F.; Wandless, T. J. J. Org. Chem. 1999, 64, 7670-7674. PDF 17. "A Stereospecific Elimination to Form Dehydroamino Acids: Synthesis of the Phomopsin Tripeptide Sidechain." Stohlmeyer, M. M.; Tanaka, H.; Wandless, T. J. J. Am. Chem. Soc., 1999, 121, 6100-6101. PDF 16. "Affinity Modulation of Small-Molecule Ligands by Borrowing Endogenous Protein Surfaces." Briesewitz, R.; Ray, G. T.; Wandless, T. J.; Crabtree, G. R. Proc. Natl. Acad. Sci. USA, 1999, 96, 1953-1958. PDF 15. "A Simple and Efficient Method for the Preparation of Hindered Alkyl–Aryl Ethers." Woiwode, T. F.; Rose, C.; Wandless, T. J. J. Org. Chem. 1998, 63, 9594-9596. PDF 14. "SH2 Domains: A Question of Independence." Wandless, T. J. Curr. Biol. 1996, 6, 125-127.PDF |
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